Gene

zgc:136908

ID
ZDB-GENE-060312-22
Name
zgc:136908
Symbol
zgc:136908 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ERAD pathway; autophagosome maturation; and mitotic spindle disassembly. Predicted to localize to VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zgc:136908 Human Ortholog
No data available
Associated With zgc:136908 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003960 ATPase, AAA-type, conserved site
Domain IPR003338 CDC48, N-terminal subdomain
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR004201 CDC48, domain 2
Domain IPR015415 Vps4 oligomerisation, C-terminal
Domain IPR041569 AAA ATPase, AAA+ lid domain
Family IPR005938 AAA ATPase, CDC48 family
Homologous_superfamily IPR009010 Aspartate decarboxylase-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR029067 CDC48 domain 2-like superfamily
Domain Details Per Protein
Protein Length AAA ATPase, AAA+ lid domain AAA ATPase, CDC48 family AAA+ ATPase domain Aspartate decarboxylase-like domain superfamily ATPase, AAA-type, conserved site ATPase, AAA-type, core CDC48, domain 2 CDC48 domain 2-like superfamily CDC48, N-terminal subdomain P-loop containing nucleoside triphosphate hydrolase Vps4 oligomerisation, C-terminal
UniProtKB:Q29RA2 805
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations