ZFIN ID: ZDB-GENE-060228-6
Gene Name: cubilin (intrinsic factor-cobalamin receptor)
Gene Symbol: cubn    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Is expressed in pronephric duct; pronephric tubule; proximal convoluted tubule; and proximal straight tubule. Orthologous to human CUBN (cubilin).
Genome Resources: Alliance (1),  Gene:100144772 (1),  Ensembl(GRCz11):ENSDARG00000087013 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pd1169 Small Deletion Unknown Unknown CRISPR
sa25216 Point Mutation Unknown Splice Site ENU
sa37922 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45836 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cubn 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cubn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    megaloblastic anemia Alliance Megaloblastic anemia-1, Finnish type 261100
    DISEASE ASSOCIATED WITH cubn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function calcium ion binding (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR000742 EGF-like domain
    Domain IPR000859 CUB domain
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR024731 EGF domain
    Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cubn-001 (1) 10941
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cubn No data available
    MARKER RELATIONSHIPS
    cubn Contained in: [BAC] CH73-48E2 (1), CH211-204I4
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021470374 (1)
    Genomic GenBank:BX000366 (1) 169542 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IIW6 (1) 3626 aa
    Sequence Information (all 12)
    ORTHOLOGY for cubn ( Chr: 24 )
    CITATIONS (19)