Gene

lgi1b

ID
ZDB-GENE-060217-1
Name
leucine-rich, glioma inactivated 1b
Symbol
lgi1b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Involved in brain morphogenesis and myelination. Predicted to localize to extracellular region. Is expressed in brain; eye; head mesenchyme; heart; and skeletal muscle. Human ortholog(s) of this gene implicated in childhood absence epilepsy and familial temporal lobe epilepsy 1. Orthologous to several human genes including LGI1 (leucine rich glioma inactivated 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Teng et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lgi1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial temporal lobe epilepsy 1 Alliance Epilepsy, familial temporal lobe, 1 600512
Associated With lgi1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
Repeat IPR009039 EAR
Domain Details Per Protein
Protein Length Cysteine-rich flanking region, C-terminal EAR Leucine-rich glioma-inactivated , EPTP repeat Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype
UniProtKB:B3DJS9 543
UniProtKB:F1R937 110
UniProtKB:Q2HPF9 407
UniProtKB:F1R662 543
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations