Gene
tanc2a
- ID
- ZDB-GENE-060130-180
- Name
- tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2a
- Symbol
- tanc2a Nomenclature History
- Previous Names
-
- tanc2
- sb:eu814
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be involved in regulation of dendritic spine morphogenesis. Predicted to be located in synapse. Predicted to be active in dendritic spine. Is expressed in hindbrain; neural rod; olfactory placode; pectoral fin; and retina. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu814 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011288Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015126Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10844 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13429 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19991 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19992 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31322 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33154 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40057 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf4039 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tanc2a | (2) | |
| CRISPR2-tanc2a | (2) | |
| CRISPR3-tanc2a | (2) | |
| CRISPR4-tanc2a | (2) | |
| CRISPR5-tanc2a | (2) | |
| CRISPR6-tanc2a | (2) | |
| CRISPR7-tanc2a | (2) | |
| CRISPR8-tanc2a | (2) | |
| CRISPR9-tanc2a | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| intellectual developmental disorder with autistic features and language delay, with or without seizures | Alliance | Intellectual developmental disorder with autistic features and language delay, with or without seizures | 618906 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR050889 | Dendritic Spine Regulation and Scaffold |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Dendritic Spine Regulation and Scaffold | P-loop containing nucleoside triphosphate hydrolase | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RE33 | InterPro | 1985 | ||||||
| UniProtKB:A0A2R8Q7B6 | InterPro | 1995 | ||||||
| UniProtKB:A0A8M9Q3C4 | InterPro | 1335 | ||||||
| UniProtKB:A0A8M9PDJ7 | InterPro | 1949 | ||||||
| UniProtKB:A0A8M9Q7F7 | InterPro | 1893 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tanc2a-201
(1)
|
Ensembl | 8,053 nt | ||
| mRNA |
tanc2a-204
(1)
|
Ensembl | 10,480 nt | ||
| mRNA |
tanc2a-205
(1)
|
Ensembl | 10,567 nt | ||
| mRNA |
tanc2a-206
(1)
|
Ensembl | 6,804 nt | ||
| ncRNA |
tanc2a-002
(1)
|
Ensembl | 520 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-1L24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-3N15 | ||
| Contained in | BAC | DKEY-35I15 | ||
| Contained in | BAC | DKEY-87J4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-203L23 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-61G11 | ZFIN Curated Data | |
| Encodes | EST | eu814 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473490 (1) | 8042 nt | ||
| Genomic | GenBank:BX005394 | 190575 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q7B6 (1) | 1995 aa |
- Long, F., Zheng, J., Zhou, J., Hu, P., Xiong, B. (2022) Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish. Autism research : official journal of the International Society for Autism Research. 16(3):524-534
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
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