ZFIN ID: ZDB-GENE-060126-2
Gene Name: Bardet-Biedl syndrome 4
Gene Symbol: bbs4    Nomenclature History

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Previous Name: zgc:152964

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Involved in several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of pigment granule localization. Is expressed in eye photoreceptor cell. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 4; morbid obesity; and obesity. Orthologous to human BBS4 (Bardet-Biedl syndrome 4).
Genome Resources: Alliance (1),  Gene:768303 (1),  Ensembl(GRCz11):ENSDARG00000063522 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa258 Point Mutation Unknown Premature Stop ENU
sa11279 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-bbs4
    1
    CRISPR2-bbs4
    1
    MO1-bbs4 N/A 13
    MO2-bbs4 N/A 3
    MO3-bbs4 N/A 3
    MO4-bbs4 N/A 2
    MO5-bbs4 N/A 1
    MO6-bbs4 N/A 1
    DISEASE ASSOCIATED WITH bbs4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bardet-Biedl syndrome 4 Alliance Bardet-Biedl syndrome 4 615982
    DISEASE ASSOCIATED WITH bbs4 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Bardet-Biedl syndrome AB/EKW + MO1-bbs4 standard conditions Wang et al., 2011
    ciliopathy AB/EKW + MO1-bbs4 standard conditions Wang et al., 2011
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axis elongation involved in somitogenesis (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript bbs4-201 (1)    Ensembl 2324
    antisense ottdart00000059890 (1) 501
    mRNA bbs4-202 (1)    Ensembl 2367
    ncRNA bbs4-002 (1)    Ensembl 779
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bbs4 No data available
    MARKER RELATIONSHIPS
    bbs4 Contained in: [BAC] CH211-117K16
    bbs4 Encodes: [cDNA] MGC:191574 (1)
    bbs4 Has Artifact: [cDNA] MGC:152964 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077466 (1) 2333 nt
    Genomic GenBank:BX957346 (1) 149598 nt
    Select Tool
    Polypeptide UniProtKB:E7EXH4 (1) 528 aa
    Sequence Information (all 17)
    ORTHOLOGY for bbs4 ( Chr: 25 )
    CITATIONS (40)