ZFIN ID: ZDB-GENE-060125-1
Gene Name: mediator complex subunit 12
Gene Symbol: med12
Sequence Ontology ID : SO:0000704

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Previous Names: kgt (1), king tut (1), kohtalo, kto, mot_m807, motionless, ott (1), otter (1), shiri (1), shr (1), thyroid hormone receptor-associated protein 230 (1), trap230 (1)

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA-binding activity transcription factor activity; involved in several processes, including animal organ development, embryonic morphogenesis, and endoderm development; predicted to  ...
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl10 Point Mutation Unknown Unknown ENU
la012521Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m807 Small Deletion Unknown Frameshift ENU
    s432 Point Mutation Unknown Premature Stop ENU
    s435 Point Mutation Unknown Premature Stop ENU
    sa6342 Point Mutation Unknown Splice Site ENU
    sa18291 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38995 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25870 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ta76b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • vu304 Point Mutation Unknown Cryptic Acceptor Splice Site, Frameshift, Premature Stop
    y81 Point Mutation Unknown Unknown ENU
    y82 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 34 figures from 13 publications
    Observed in:
    DISEASE ASSOCIATED WITH med12 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    FG syndrome Opitz-Kaveggia syndrome 305450
    Ohdo syndrome Ohdo syndrome, X-linked 300895
    Lujan-Fryns syndrome 309520
    DISEASE ASSOCIATED WITH med12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic pectoral fin morphogenesis (more)
    Cellular Component mediator complex (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR019035 (1)
  • InterPro:IPR021989 (1)
  • InterPro:IPR021990 (1)
  • Pfam:PF09497 (1)
  • Pfam:PF12144 (1)
  • Pfam:PF12145 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA med12-201 (1) 825
    med12-202 (1) 6924
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM med12 No data available
    MARKER RELATIONSHIPS
    med12Contained in: [BAC] CH211-66G21 (1) (order this), CH211-119P14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039461 (1) 6951bp
    Genomic RefSeq:NW_018394907 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QEP6 (1) 2188aa
    Sequence Clusters UniGene:41439 (1)
    Sequence Information (all 25)
    OTHER med12 GENE PAGES
  • Alliance (1)
  • Gene:566632 (1)
  • VEGA:OTTDARG00000034923 (1)
  • ORTHOLOGY for med12 (Chr: 14)
    CITATIONS (45)