ZFIN Gene: lama1

ZFIN ID: ZDB-GENE-060118-1

ZFIN ID: ZDB-GENE-060118-1

Gene Name:

laminin, alpha 1

Gene Symbol:

lama1 Nomenclature History

Previous Names:

bal, bashful, zmp:0000000656 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Predicted to have extracellular matrix structural constituent. Involved in several processes, including camera-type eye development; nervous system development; and notochord cell development. Predicted to localize to basement membrane. Is expressed in several structures, including central nervous system; eye; immature eye; pronephros; and trunk. Orthologous to human LAMA1 (laminin subunit alpha 1).

Genome Resources:

Alliance (1), Gene:569971 (1), Ensembl(GRCz11):ENSDARG00000102277 (1)

GENE EXPRESSION
All Expression Data:	14 figures from 10 publications
Wild-type Stages, Structures:	Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
	brain central nervous system anterior region cornea eye head immature eye lens myotome neural tube notochord optic fissure optic furrow otic vesicle pectoral fin pharyngeal arch 3-7 pronephric duct pronephric duct opening pronephros retina segmental plate solid lens vesicle somite spinal cord trunk unspecified vasculature whole organism
High Throughput Expression:	Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
a69	Point Mutation	Unknown	Missense
b765	Unknown	Unknown	Unknown
lama1_unspecified	Unspecified	Unknown	Unknown
m102	Unknown	Unknown	Unknown	ENU
m113	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m190	Point Mutation	Unknown	Premature Stop	ENU
m255	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m268	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m277	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m290	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m296	Unknown	Unknown	Unknown	ENU
m373	Unknown	Unknown	Unknown	ENU
m430	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m473	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
nt7	Point Mutation	Unknown	Premature Stop	ENU
rw88	Unknown	Unknown	Unknown
sa10397	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13584	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17699	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24576	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa37969	Point Mutation	Unknown	Missense, Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44203	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44204	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tb244f	Unknown	Unknown	Unknown	ENU
tc245a	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tc248f	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tf209	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tf235	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tm220a	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tm267a	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
to265	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tp82	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tp86	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tq210	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tr203	Unknown	Unknown	Unknown	ENU
tr259	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tt206	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tv36	Unknown	Unknown	Unknown	ENU
uw1	Point Mutation	Unknown	Splice Site

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-lama1	N/A	4
MO2-lama1	N/A	5
MO3-lama1	N/A	1
MO4-lama1	N/A	1
MO5-lama1	N/A	4
MO6-lama1	N/A	1

PHENOTYPE

Data:

67 figures from 17 publications

Observed in:

DISEASE ASSOCIATED WITH lama1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Poretti-Boltshauser syndrome	615960

DISEASE ASSOCIATED WITH lama1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	blood vessel development (more)
Cellular Component	basement membrane (more)
Molecular Function	signaling receptor binding (more)

GO Terms (all 31)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	lama1-201 (1)	9581	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM lama1

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
TgBAC(lama1:EGFP)	lama1	EGFP	Danio rerio	1	1
TgBAC(lama1:lama1-EGFP)	lama1	EGFP, lama1	Danio rerio	1	1

MARKER RELATIONSHIPS

lama1 Contained in:

[BAC] CH73-38N6 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001034986 (1)	9582 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:FP101885 (1)	130902 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4II20 (1)	3075 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 12)

ORTHOLOGY for lama1 ( Chr: 24 )

CITATIONS (72)

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