ZFIN ID: ZDB-GENE-060110-2
Gene Name: solute carrier family 8 member 4a
Gene Symbol: slc8a4a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: ncx4a (2)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Exhibits calcium:sodium antiporter activity. Involved in several processes, including heart contraction; heart looping; and skeletal muscle tissue development. Predicted to localize to membrane. Is expressed in several structures, including Kupffer's vesicle; blood; digestive system; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
Genome Resources: Alliance (1),  Gene:568512 (1),  Ensembl(GRCz11):ENSDARG00000055154 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028336Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37329 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37330 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39332 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc8a4a N/A 2
    MO2-slc8a4a N/A 1
    DISEASE ASSOCIATED WITH slc8a4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH slc8a4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component membrane (more)
    Molecular Function calcium:sodium antiporter activity (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc8a4a-202 (1)    Ensembl 4448
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc8a4a No data available
    MARKER RELATIONSHIPS
    slc8a4a Contained in: [BAC] CH211-10O1
    slc8a4a Encodes: [cDNA] MGC:194730 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089419 (1) 2820 nt
    Genomic GenBank:BX324159 (1) 178610 nt
    Select Tool
    Polypeptide UniProtKB:A4UQV6 (1) 939 aa
    Sequence Information (all 21)
    ORTHOLOGY for slc8a4a ( Chr: 21 )
    CITATIONS (26)