ZFIN ID: ZDB-GENE-051220-1
Gene Name: LIM homeobox 2b
Gene Symbol: lhx2b    Nomenclature History

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Previous Names: lhx2, bel, belladonna, zgc:152707

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervous system development; and optomotor response. Predicted to localize to nucleus. Is expressed in several structures, including brain; forebrain neural keel; forebrain neural rod; optic vesicle; and retina. Used to study congenital nystagmus and pathologic nystagmus. Orthologous to human LHX2 (LIM homeobox 2).
Genome Resources: Alliance (1),  Gene:791744 (1),  Ensembl(GRCz11):ENSDARG00000031222 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b700 Small Deletion Exon 3 Frameshift, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ihb61 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb62 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb63 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • lhx2b_unspecified Unspecified Unknown Unknown
    s385 Unknown Unknown Unknown ENU
    sa6091 Point Mutation Unknown Premature Stop ENU
    sa21179 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tv42z Point Mutation Exon 2 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lhx2b 1
    MO1-lhx2b N/A 3
    MO2-lhx2b N/A 1
    MO3-lhx2b N/A 1
    DISEASE ASSOCIATED WITH lhx2b HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process thalamus development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lhx2b-201 (1)    Ensembl 869
    lhx2b-202 (1)    Ensembl 3677
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lhx2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(lhx2b:GAL4-VP16,myl7:mCherry) lhx2bmyl7 GAL4mCherryVP16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    lhx2b Contained in: [BAC] CH211-146J7 (1), CH211-159C13 (1)
    lhx2b Encodes: [cDNA] MGC:152707 (1), MGC:191665 (1), MGC:193772 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040010 (1) 3602 nt
    Genomic GenBank:BX005074 (1) 153989 nt
    Select Tool
    Polypeptide UniProtKB:B0R107 (1) 427 aa
    Sequence Information (all 32)
    ORTHOLOGY for lhx2b ( Chr: 8 )
    CITATIONS (62)