ZFIN ID: ZDB-GENE-051202-2
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1b
Gene Symbol: grin1b    Nomenclature History

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Previous Names: NMDAR1.2 (1), si:rp71-1o1.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to localize to NMDA selective glutamate receptor complex; neuron projection; and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Genome Resources: Alliance (1),  Gene:100005675 (1),  Ensembl(GRCz11):ENSDARG00000025728 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024950Tg Transgenic Insertion Unknown Unknown DNA
sa6056 Point Mutation Unknown Splice Site ENU
sa10811 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18803 Point Mutation Unknown Premature Stop ENU
    sa40455 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grin1b
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grin1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 8 Alliance Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 614254
    Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive 617820
    DISEASE ASSOCIATED WITH grin1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grin1b-201 (1)    Ensembl 3728
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grin1b No data available
    MARKER RELATIONSHIPS
    grin1b Contained in: [BAC] CH211-215C18 (1), RP71-1O1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001144131 (1)
    Genomic GenBank:BX276128 (1) 176461 nt
    Select Tool
    Polypeptide UniProtKB:Q6ZM67 (1) 937 aa
    Sequence Information (all 15)
    ORTHOLOGY for grin1b ( Chr: 5 )
    CITATIONS (44)