Gene

grin1a

ID
ZDB-GENE-051202-1
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
Symbol
grin1a Nomenclature History
Previous Names
  • NMDA receptor glycine-binding subunit NR1.1 (1)
  • NMDAR1.1 (1)
  • zgc:152678
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Enables ligand-gated monoatomic ion channel activity. Involved in calcium ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Zoodsma et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 8 Alliance Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 614254
Developmental and epileptic encephalopathy 101 619814
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive 617820
Associated With grin1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor
Domain IPR001828 Receptor, ligand binding region
Domain IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family IPR000337 GPCR, family 3
Family IPR001508 Ionotropic glutamate receptor, metazoa
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Calmodulin-binding domain C0, NMDA receptor, NR1 subunit GPCR, family 3 Ionotropic glutamate receptor Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:A0A0B5JFI5 226
UniProtKB:E7F101 966
UniProtKB:Q1RM76 191
UniProtKB:Q08CV1 226
UniProtKB:E7EYT4 938
UniProtKB:F1R366 901
UniProtKB:Q504C5 195
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations