ZFIN ID: ZDB-GENE-051202-1
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1a
Gene Symbol: grin1a    Nomenclature History

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Previous Names: NMDA receptor glycine-binding subunit NR1.1 (1), NMDAR1.1 (1), zgc:152678

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have NMDA glutamate receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and ion transport. Predicted to localize to the NMDA selective glutamate receptor complex. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Genome Resources: Alliance (1),  Gene:767745 (1),  Ensembl(GRCz11):ENSDARG00000027828 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa133 Point Mutation Unknown Premature Stop ENU
sa7245 Point Mutation Unknown Splice Site ENU
sa25151 Point Mutation Unknown Splice Site ENU
sa37246 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grin1a
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grin1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 8 Alliance Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 614254
    Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive 617820
    DISEASE ASSOCIATED WITH grin1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component cell junction (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001320 Ionotropic glutamate receptor
    Domain IPR001828 Receptor, ligand binding region
    Domain IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
    Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    Family IPR000337 GPCR, family 3
    Family IPR001508 Ionotropic glutamate receptor, metazoa
    Homologous_superfamily IPR028082 Periplasmic binding protein-like I
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grin1a-201 (1)    Ensembl 1248
    grin1a-202 (1)    Ensembl 4549
    grin1a-203 (1)    Ensembl 2847
    grin1a-204 (1)    Ensembl 2933
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grin1a No data available
    MARKER RELATIONSHIPS
    grin1a Contained in: [BAC] DKEY-184P9 (1) (order this)
    grin1a Encodes: [cDNA] MGC:152678
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076714 (1) 1253 nt
    Genomic GenBank:BX005379 (1) 185814 nt
    Select Tool
    Polypeptide UniProtKB:E7F101 (1) 966 aa
    Sequence Information (all 40)
    ORTHOLOGY for grin1a ( Chr: 21 )
    CITATIONS (41)