ZFIN ID: ZDB-GENE-051120-81
Gene Name: F-box and leucine-rich repeat protein 8
Gene Symbol: fbxl8    Nomenclature History

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Previous Name: zgc:123259

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to localize to the SCF ubiquitin ligase complex. Orthologous to human FBXL8 (F-box and leucine rich repeat protein 8).
Genome Resources: Alliance (1),  Gene:641481 (1),  Ensembl(GRCz11):ENSDARG00000054222 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fbxl8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fbxl8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G2/M transition of mitotic cell cycle (more)
    Cellular Component cytosol (more)
    Molecular Function CONTRIBUTES_TO   ubiquitin protein ligase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001810 F-box domain
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036047 F-box-like domain superfamily
    Family IPR039592 F-box/LRR-repeat protein 8
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fbxl8-201 (1)    Ensembl 3534
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fbxl8 No data available
    MARKER RELATIONSHIPS
    fbxl8 Contained in: [BAC] DKEY-97O18 (1) (order this), DKEYP-109H3 (1)
    fbxl8 Encodes: [cDNA] MGC:123259 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001037422 (1) 1835 bp
    Genomic GenBank:CR352249 (1) 180142 bp
    Select Tool
    Polypeptide UniProtKB:F1QN14 (1) 367 aa
    Sequence Information (all 13)
    ORTHOLOGY for fbxl8 ( Chr: 7 )
    CITATIONS (15)