ZFIN ID: ZDB-GENE-051113-320
Gene Name: TRAF2 and NCK interacting kinase b
Gene Symbol: tnikb    Nomenclature History

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Previous Names: im:6898857, zgc:123033, zgc:152783

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in activation of protein kinase activity; intracellular signal transduction; and neuron projection morphogenesis. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in central nervous system; neural plate; retina; and ventral mesoderm. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
Genome Resources: Alliance (1),  Gene:556959 (1),  Ensembl(GRCz11):ENSDARG00000009031 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:6898857]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014560Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022950Tg Transgenic Insertion Unknown Unknown DNA
    la028628Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6774 Point Mutation Unknown Premature Stop ENU
    sa37905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44157 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-tnikb
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tnikb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 54 617028
    DISEASE ASSOCIATED WITH tnikb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR001180 Citron homology (CNH) domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnikb-201 (1)    Ensembl 4370
    tnikb-202 (1)    Ensembl 2009
    ncRNA tnikb-003 (1) 1608
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnikb No data available
    MARKER RELATIONSHIPS
    tnikb Contained in: [BAC] CH211-230G15 (1), DKEY-70N11 (1) (order this)
    tnikb Encodes: [EST] IMAGE:6898857 (1)
    [cDNA] MGC:123033 (1), MGC:152783 (1), MGC:192776 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001037676 (1) 2140 nt
    Genomic GenBank:CR354593 (1) 128945 nt
    Select Tool
    Polypeptide UniProtKB:F1QQG8 (1) 543 aa
    Sequence Information (all 44)
    ORTHOLOGY for tnikb ( Chr: 24 )
    CITATIONS (27)