Gene

il10

ID
ZDB-GENE-051111-1
Name
interleukin 10
Symbol
il10 Nomenclature History
Previous Names
  • zgc:194510
  • zgc:194518
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have cytokine activity. Involved in defense response to bacterium and response to lipopolysaccharide. Predicted to localize to extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Genome Resources
Note
None
Expression
All Expression Data
35 figures from 27 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
rheumatoid arthritis Alliance {Rheumatoid arthritis, progression of} 180300
{Graft-versus-host disease, protection against} 614395
{HIV-1, susceptibility to} 609423
Associated With il10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000098 Interleukin-10
Family IPR020443 Interleukin-10/19/20/22/24/26 family
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Interleukin-10 Interleukin-10/19/20/22/24/26 family
UniProtKB:Q5EFQ8 180
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations