ZFIN ID: ZDB-GENE-051108-1
Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase b
Gene Symbol: hmgcrb
Sequence Ontology ID : SO:0000704

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Previous Names: hmgcr1b, hmgcr2 (1), hmgrb (1), im:6912716, zgc:110746

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
GENE EXPRESSION
All Expression Data: 8 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6912716]
  2 figures (2 images) from Thisse et al., 2004 [IMAGE:6904727]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014029Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s617 Point Mutation Unknown Missense ENU
    Targeting reagents:
    PHENOTYPE
    Data: 9 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH hmgcrb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    [Low density lipoprotein cholesterol level QTL 3]
    [Statins, attenuated cholesterol lowering by]
    DISEASE ASSOCIATED WITH hmgcrb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel maturation (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function coenzyme binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000731 (1)
  • InterPro:IPR002202 (1)
  • InterPro:IPR004554 (1)
  • InterPro:IPR004816 (1)
  • InterPro:IPR009023 (1)
  • InterPro:IPR009029 (1)
  • InterPro:IPR023074 (1)
  • InterPro:IPR023076 (1)
  • InterPro:IPR023282 (1)
  • PROSITE:PS00066 (1)
  • PROSITE:PS00318 (1)
  • PROSITE:PS01192 (1)
  • PROSITE:PS50065 (1)
  • PROSITE:PS50156 (1)
  • Pfam:PF00368 (1)
  • Pfam:PF12349 (1)
  • EC:1.1.1.34 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hmgcrb-001 (1) 3424
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM hmgcrb No data available
    MARKER RELATIONSHIPS
    hmgcrbContained in: [BAC] CH211-149I8 (order this)
    hmgcrbEncodes: [EST] IMAGE:6904727 (1) (order this), IMAGE:6912716 (1) (order this)
    [cDNA] MGC:110746 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014292 (1) 3445bp
    Genomic GenBank:CR318660 (1) 162045bp
    Select Tool
    Polypeptide UniProtKB:Q58ER2 (1) 845aa
    Sequence Clusters UniGene:88727 (1)
    Sequence Information (all 12)
    OTHER hmgcrb GENE PAGES
  • Alliance (1)
  • Gene:541479 (1)
  • VEGA:OTTDARG00000022632 (1)
  • Ensembl(GRCz11):ENSDARG00000105206 (1)
  • ORTHOLOGY for hmgcrb (Chr: 21)
    CITATIONS (59)