Gene

nedd4a

ID

ZDB-GENE-051005-2

Name

NEDD4 E3 ubiquitin protein ligase a

Symbol

nedd4a Nomenclature History

Previous Names

si:ch211-79l17.5

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within endothelial to hematopoietic transition and negative regulation of Notch signaling pathway. Predicted to be located in cytoplasm. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zhang et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nedd4a Human Ortholog

No data available

Associated With nedd4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Family	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily