ZFIN ID: ZDB-GENE-050913-84
Gene Name: dynamin 2a
Gene Symbol: dnm2a    Nomenclature History

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Previous Names: dnm2, zgc:114072

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have GTPase activity and microtubule binding activity. Involved in several processes, including chordate embryonic development; convergent extension; and somite development. Predicted to localize to several cellular components, including dendritic spine head; postsynaptic density; and postsynaptic endocytic zone membrane. Is expressed in several structures, including central nervous system; liver; otic vesicle; paraxial mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2).
Genome Resources: Alliance (1),  Gene:559334 (1),  Ensembl(GRCz11):ENSDARG00000069937 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024273Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9093 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13248 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13768 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15133 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16501 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17720 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20128 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20129 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20130 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dnm2a N/A 3
    MO2-dnm2a N/A 1
    MO3-dnm2a N/A 1
    MO4-dnm2a N/A 1
    DISEASE ASSOCIATED WITH dnm2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    centronuclear myopathy 1 Alliance Centronuclear myopathy 1 160150
    Charcot-Marie-Tooth disease dominant intermediate B Alliance Charcot-Marie-Tooth disease, axonal type 2M 606482
    Charcot-Marie-Tooth disease, dominant intermediate B 606482
    Lethal congenital contracture syndrome 5 615368
    DISEASE ASSOCIATED WITH dnm2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension (more)
    Cellular Component microtubule (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnm2a-201 (1)    Ensembl 2573
    ncRNA dnm2a-002 (1)    Ensembl 638
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dnm2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.8ctbp2a:dnm2a-EGFP) ctbp2a dnm2aEGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    dnm2a Contained in: [BAC] CH211-286H12 (1)
    dnm2a Encodes: [cDNA] MGC:114072 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030128 (1) 2589 nt
    Genomic GenBank:BX088529 (1) 178667 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IIR1 (1) 860 aa
    Sequence Information (all 29)
    ORTHOLOGY for dnm2a ( Chr: 3 )
    CITATIONS (31)