Gene
sppl3
- ID
- ZDB-GENE-050913-71
- Name
- signal peptide peptidase 3
- Symbol
- sppl3 Nomenclature History
- Previous Names
-
- fb94d08
- wu:fb94d08
- zgc:114093
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Acts upstream of or within regulation of neuron apoptotic process. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Is expressed in central nervous system. Orthologous to human SPPL3 (signal peptide peptidase like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) UCSC scRNA-seq (1)
- Thisse Expression Data
-
- MGC:114093 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Peptidase A22B, signal peptide peptidase | Presenilin/signal peptide peptidase |
|---|---|---|---|
|
UniProtKB:F1RDS1
|
345 | ||
|
UniProtKB:Q5BP97
|
382 | ||
|
UniProtKB:Q4V8X9
|
345 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available