Gene

rab27a

ID
ZDB-GENE-050913-46
Name
RAB27A, member RAS oncogene family
Symbol
rab27a Nomenclature History
Previous Names
  • zgc:114135 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have GTP binding activity and GTPase activity. Predicted to be involved in melanosome transport and positive regulation of exocytosis. Predicted to localize to melanosome and secretory granule. Is expressed in cloaca; nervous system; and pronephric tubule. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to human RAB27A (RAB27A, member RAS oncogene family).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Wuttke et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rab27a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Griscelli syndrome, type 2 607624
Associated With rab27a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR041837 Rab27a/b
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Rab27a/b Small GTPase Small GTP-binding protein domain
UniProtKB:Q4V8U8 222
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations