ZFIN ID: ZDB-GENE-050913-153
Gene Name: BarH-like homeobox 2
Gene Symbol: barhl2    Nomenclature History

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Previous Names: wu:fq39g04, zgc:113948

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; regulation of transcription by RNA polymerase II; and tissue development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Is expressed in alar plate midbrain region; nervous system; neural plate; and presumptive diencephalon. Orthologous to human BARHL2 (BarH like homeobox 2).
Genome Resources: Alliance (1),  Gene:100001699 (1),  Ensembl(GRCz11):ENSDARG00000104361 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33851 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-barhl2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH barhl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH barhl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR020479 Homeobox domain, metazoa
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA barhl2-202 (1)    Ensembl 1711
    ncRNA barhl2-002 (1)    Ensembl 766
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM barhl2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(barhl2:GFP) barhl2 GFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    barhl2 Contained in: [BAC] CH211-15L16 (1)
    barhl2 Encodes: [EST] eu113 (1), fq39g04 (1) (order this)
    [cDNA] MGC:113948 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205740 (1) 1721 bp
    Genomic GenBank:CR385085 (1) 211060 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q4V975 (1) 364 aa
    Sequence Clusters UniGene:79590 (1)
    Sequence Information (all 14)
    ORTHOLOGY for barhl2 ( Chr: 6 )
    CITATIONS (40)