Gene

grhl2a

ID
ZDB-GENE-050913-123
Name
grainyhead-like transcription factor 2a
Symbol
grhl2a Nomenclature History
Previous Names
  • zgc:110324
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in olfactory placode; otic placode; otic vesicle; pronephric duct; and pronephros. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dworkin et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grhl2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 28 Alliance Deafness, autosomal dominant 28 608641
posterior polymorphous corneal dystrophy 4 Alliance Corneal dystrophy, posterior polymorphous, 4 618031
Ectodermal dysplasia/short stature syndrome 616029
Associated With grhl2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007604 CP2 transcription factor
Domain Details Per Protein
Protein Length CP2 transcription factor
UniProtKB:Q4V9N3 348
UniProtKB:F8W5L7 593
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations