ZFIN ID: ZDB-GENE-050913-117
Gene Name: catechol-O-methyltransferase a
Gene Symbol: comta    Nomenclature History

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Previous Name: zgc:114157 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits catechol O-methyltransferase activity. Involved in methylation. Predicted to localize to extracellular region and integral component of membrane. Is expressed in several structures, including digestive system; male organism; nervous system; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase).
Genome Resources: Alliance (1),  Gene:561372 (1),  Ensembl(GRCz11):ENSDARG00000015337 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH comta HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
panic disorder Alliance {Panic disorder, susceptibility to} 167870
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
DISEASE ASSOCIATED WITH comta VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process methylation (more)
Cellular Component extracellular region (more)
Molecular Function catechol O-methyltransferase activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA comta-202 (1)    Ensembl 1032
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM comta
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(myo6b:comta-EGFP) myo6b comtaEGFP Danio rerio 1 1
Tg(myo6b:comta-emGFP) myo6b comtaemGFP Danio rerio 1 1
MARKER RELATIONSHIPS
comta Contained in: [BAC] DKEY-52H10 (1) (order this)
comta Encodes: [cDNA] MGC:114157 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001030157 (1) 899 nt
Genomic GenBank:CR457452 (1) 232104 nt Blast at MegaBLAST
Polypeptide UniProtKB:B0UYJ6 (1) 277 aa
Sequence Information (all 14)
ORTHOLOGY for comta ( Chr: 8 )
CITATIONS (30)