ZFIN ID: ZDB-GENE-050909-1
Gene Name: interleukin 10 receptor, beta
Gene Symbol: il10rb    Nomenclature History

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Previous Names: IL10R2 (1), il10rbl, crfb5, zgc:153823

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits interferon receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B; hepatitis C; and inflammatory bowel disease 25. Is expressed in head and heart. Orthologous to several human genes including IFNAR1 (interferon alpha and beta receptor subunit 1).
Genome Resources: Alliance (1),  Gene:619391 (1),  Ensembl(GRCz11):ENSDARG00000078042 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Levraud et al., 2007
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3147Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-il10rb
    1
    CRISPR2-il10rb
    1
    MO1-il10rb N/A 3
    MO2-il10rb N/A 2
    MO3-il10rb N/A 1
    DISEASE ASSOCIATED WITH il10rb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    inflammatory bowel disease 25 Alliance Inflammatory bowel disease 25, early onset, autosomal recessive 612567
    {Hepatitis B virus, susceptibility to} 610424
    DISEASE ASSOCIATED WITH il10rb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process immune response-activating signal transduction (more)
    Cellular Component integral component of membrane (more)
    Molecular Function interferon receptor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003961 Fibronectin type III
    Domain IPR015373 Interferon/interleukin receptor domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA il10rb-201 (1)    Ensembl 594
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM il10rb No data available
    MARKER RELATIONSHIPS
    il10rb Contained in: [Fosmid] CH1073-55A19 (1)
    il10rb Encodes: [cDNA] MGC:153823 (1), MGC:191586 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034185 (1) 1597 nt
    Genomic GenBank:CU638712 (1) 35166 nt
    Select Tool
    Polypeptide UniProtKB:A0FJI0 (1) 368 aa
    Sequence Information (all 34)
    ORTHOLOGY for il10rb ( Chr: 9 )
    CITATIONS (34)