Gene

cish

ID
ZDB-GENE-050907-1
Name
cytokine inducible SH2-containing protein
Symbol
cish Nomenclature History
Previous Names
  • wu:fk57g04
  • zgc:154062 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of erythrocyte differentiation; negative regulation of lymphocyte differentiation; and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to localize to phosphatidylinositol 3-kinase complex. Is expressed in blastomere; pronephric duct; thymus; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Lewis et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cish Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Bacteremia, susceptibility to} 614383
{Malaria, susceptibility to} 611162
{Tuberculosis, susceptibility to} 607948
Associated With cish Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR001496 SOCS box domain
Domain IPR035887 CIS, SH2 domain
Family IPR028425 Cytokine-inducible SH2-containing protein
Homologous_superfamily IPR036036 SOCS box-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length CIS, SH2 domain Cytokine-inducible SH2-containing protein SH2 domain SH2 domain superfamily SOCS box domain SOCS box-like domain superfamily
UniProtKB:E9QCT0 173
UniProtKB:E9QCE7 31
UniProtKB:Q08BW5 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations