ZFIN ID: ZDB-GENE-050907-1
Gene Name: cytokine inducible SH2-containing protein
Gene Symbol: cish
Sequence Ontology ID : SO:0000704

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Previous Names: wu:fk57g04, zgc:154062 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have 1-phosphatidylinositol-3-kinase regulator activity; involved in negative regulation of JAK-STAT cascade, negative regulation of erythrocyte differentiation, and negative regulation  ...
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE
Data: 4 figures from Lewis et al., 2014
Observed in:
DISEASE ASSOCIATED WITH cish HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
{Bacteremia, susceptibility to} 614383
{Malaria, susceptibility to} 611162
{Tuberculosis, susceptibility to} 607948
DISEASE ASSOCIATED WITH cish VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of erythrocyte differentiation (more)
Cellular Component cytoplasm (more)
Molecular Function protein kinase inhibitor activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000980 (1)
  • InterPro:IPR001496 (1)
  • InterPro:IPR028425 (1)
  • InterPro:IPR035887 (1)
  • InterPro:IPR036036 (1)
  • InterPro:IPR036860 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50225 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF07525 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cish-001 (1) 1421
    cish-002 (1) 497
    cish-003 (1) 1038
    ncRNA cish-004 (1) 429
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cish No data available
    MARKER RELATIONSHIPS
    cishContained in: [BAC] DKEY-98D20 (order this)
    cishEncodes: [EST] fk57g04 (1)
    [cDNA] MGC:154062 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001076617 (1)
    Genomic GenBank:CR847825 (1) 113362bp
    Select Tool
    Polypeptide UniProtKB:Q08BW5 (1) 212aa
    Sequence Clusters UniGene:74191 (1)
    Sequence Information (all 21)
    OTHER cish GENE PAGES
  • Alliance (1)
  • Gene:767678 (1)
  • VEGA:OTTDARG00000027298 (1)
  • Ensembl(GRCz11):ENSDARG00000060316 (2)
  • ORTHOLOGY for cish (Chr: 6)
    CITATIONS (28)