Gene

magi2a

ID
ZDB-GENE-050810-4
Name
membrane associated guanylate kinase, WW and PDZ domain containing 2a
Symbol
magi2a Nomenclature History
Previous Names
  • magi2
  • fb82g11
  • si:dkey-97c7.1 (1)
  • si:dkeyp-86a5.1
  • wu:fb82g11
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Involved in pronephric glomerulus development. Predicted to localize to cell-cell junction; cytoplasm; and dendrite. Is expressed in pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dong et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With magi2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephrotic syndrome type 15 Alliance Nephrotic syndrome, type 15 617609
Associated With magi2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020590 Guanylate kinase, conserved site
Domain IPR001202 WW domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR041489 PDZ domain 6
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036020 WW domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length Guanylate kinase, conserved site Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit PDZ domain PDZ domain 6 PDZ superfamily P-loop containing nucleoside triphosphate hydrolase WW domain WW domain superfamily
UniProtKB:A0A2R8PV45 1046
UniProtKB:A0A2R8QD15 445
UniProtKB:A0A2R8Q2T9 820
UniProtKB:Q5VSD9 1274
UniProtKB:A0A2R8Q8D8 1081
UniProtKB:A0A2R8QJF4 1093
UniProtKB:A0A2R8QBW2 524
UniProtKB:F1Q897 1503
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations