ZFIN ID: ZDB-GENE-050810-4
Gene Name: membrane associated guanylate kinase, WW and PDZ domain containing 2a
Gene Symbol: magi2a    Nomenclature History

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Previous Names: magi2, fb82g11, si:dkey-97c7.1 (1), si:dkeyp-86a5.1, wu:fb82g11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Involved in pronephric glomerulus development. Predicted to localize to cell-cell junction; cytoplasm; and dendrite. Is expressed in pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
Genome Resources: Alliance (1),  Gene:564112 (1),  Ensembl(GRCz11):ENSDARG00000021590 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cl604 Indel Unknown Unknown
cl605 Indel Unknown Unknown
cl606 Indel Unknown Unknown
cl607 Indel Unknown Unknown
la024508Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024509Tg Transgenic Insertion Unknown Unknown DNA
    sa9085 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17077 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18564 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20277 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30610 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30850 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40297 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-magi2a 1
    MO1-magi2a N/A 1
    PHENOTYPE
    Data: Fig. 5 from Dong et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH magi2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nephrotic syndrome type 15 Alliance Nephrotic syndrome, type 15 617609
    DISEASE ASSOCIATED WITH magi2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephric glomerulus development (more)
    Cellular Component bicellular tight junction (more)
    Molecular Function molecular adaptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA magi2a-202 (1)    Ensembl 3825
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM magi2a No data available
    MARKER RELATIONSHIPS
    magi2a Contained in: [BAC] DKEY-27K7 (1) (order this), DKEY-47F13 (1) (order this), DKEY-97C7 (1) (order this), DKEYP-86A5 (1)
    magi2a Encodes: [EST] fb82g11
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001122611 (1) 3825 nt
    Genomic RefSeq:NW_018394554 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q897 (1) 1503 aa
    Sequence Information (all 47)
    ORTHOLOGY for magi2a ( Chr: 4 )
    CITATIONS (28)