ZFIN ID: ZDB-GENE-050810-4
Gene Name: membrane associated guanylate kinase, WW and PDZ domain containing 2a
Gene Symbol: magi2a    Nomenclature History

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Previous Names: magi2, fb82g11, si:dkey-97c7.1 (1), si:dkeyp-86a5.1, wu:fb82g11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity; receptor signaling complex adaptor activity; and signaling receptor binding activity. Involved in pronephric glomerulus development. Predicted to localize to the cell-cell junction; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Is expressed in pronephric glomerulus. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
Genome Resources: Alliance (1),  Gene:564112 (1),  Ensembl(GRCz11):ENSDARG00000021590 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cl604 Indel Unknown Unknown
cl605 Indel Unknown Unknown
cl606 Indel Unknown Unknown
cl607 Indel Unknown Unknown
la024508Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024509Tg Transgenic Insertion Unknown Unknown DNA
    sa9085 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17077 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18564 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20277 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30610 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30850 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40297 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-magi2a 1
    MO1-magi2a N/A 1
    PHENOTYPE
    Data: Fig. 5 from Dong et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH magi2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nephrotic syndrome type 15 Alliance Nephrotic syndrome, type 15 617609
    DISEASE ASSOCIATED WITH magi2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephric glomerulus development (more)
    Cellular Component bicellular tight junction (more)
    Molecular Function molecular adaptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001202 WW domain
    Domain IPR001478 PDZ domain
    Domain IPR008144 Guanylate kinase-like domain
    Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    Conserved_site IPR020590 Guanylate kinase, conserved site
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Family IPR030036 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    Homologous_superfamily IPR036020 WW domain superfamily
    Homologous_superfamily IPR036034 PDZ superfamily
    Domain IPR041489 PDZ domain 6
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA magi2a-202 (1)    Ensembl 3825
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM magi2a No data available
    MARKER RELATIONSHIPS
    magi2a Contained in: [BAC] DKEY-27K7 (1) (order this), DKEY-47F13 (1) (order this), DKEY-97C7 (1) (order this), DKEYP-86A5 (1)
    magi2a Encodes: [EST] fb82g11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001122611 (1) 3825 bp
    Genomic RefSeq:NW_018394554 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q897 (1) 1503 aa
    Sequence Information (all 47)
    ORTHOLOGY for magi2a ( Chr: 4 )
    CITATIONS (28)