vps16

ID

ZDB-GENE-050809-9

Name

VPS16 core subunit of CORVET and HOPS complexes

Symbol

vps16 Nomenclature History

Previous Names

im:6907749
wu:fc34a07
wu:fl62a06
zgc:162584

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin binding activity. Acts upstream of or within several processes, including habituation; regulation of myelination; and swimming behavior. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in endosome. Used to study lysosomal storage disease. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907749 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps16 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dystonia 30	Alliance	Dystonia 30	619291

Associated With vps16 Via Experimental Models

Human Disease	Fish	Conditions	Citations
lysosomal storage disease	AB + CRISPR1-vps16	standard conditions	Sofou et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006925	Vps16, C-terminal
Domain	IPR006926	Vps16, N-terminal
Family	IPR016534	Vacuolar protein sorting-associated protein 16
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR038132	Vps16, C-terminal domain superfamily