Gene
trrap
- ID
- ZDB-GENE-050809-47
- Name
- transformation/transcription domain-associated protein
- Symbol
- trrap Nomenclature History
- Previous Names
-
- fc54d09
- im:7154030
- wu:fc54d09
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Involved in neuromast hair cell development and startle response. Predicted to be part of NuA4 histone acetyltransferase complex and SAGA complex. Predicted to be active in nucleus. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154030 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Xia et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 75 | Alliance | ?Deafness, autosomal dominant 75 | 618778 |
| Developmental delay with or without dysmorphic facies and autism | 618454 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness | trrapzf3166/+ | standard conditions | Xia et al., 2019 |
| autosomal dominant nonsyndromic deafness | AB + MO2-trrap | standard conditions | Xia et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR014009 | PIK-related kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR046805 | Tra1, HEAT repeat ring region |
| Repeat | IPR046807 | Tra1, HEAT repeat central region |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tra1, HEAT repeat central region | Tra1, HEAT repeat ring region |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B4M5
|
3839 | |||||||||
|
UniProtKB:A0A8M9PMB6
|
1273 | |||||||||
|
UniProtKB:A0A0R4IPE4
|
3834 | |||||||||
|
UniProtKB:A0A0R4ITC5
|
3841 |
Interactions and Pathways
No data available
Plasmids
No data available