Gene

wfs1b

ID
ZDB-GENE-050809-19
Name
Wolfram syndrome 1b (wolframin)
Symbol
wfs1b Nomenclature History
Previous Names
  • im:7150991
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wfs1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 6 Alliance Deafness, autosomal dominant 6/14/38 600965
autosomal dominant Wolfram syndrome Alliance Wolfram-like syndrome, autosomal dominant 614296
cataract 41 Alliance ?Cataract 41 116400
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent, association with} 125853
Wolfram syndrome 1 Alliance Wolfram syndrome 1 222300
Associated With wfs1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR026208 Wolframin
Family IPR026209 Wolframin family
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Domain Details Per Protein
Protein Length Tetratricopeptide-like helical domain superfamily Wolframin Wolframin family
UniProtKB:E7F921 895
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations