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General Information
ZIRC
ZFIN ID: ZDB-GENE-050809-129
Gene Name: biogenesis of lysosomal organelles complex-1, subunit 2
Gene Symbol: bloc1s2
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:111974

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have gamma-tubulin binding activity. Involved in negative regulation of Notch signaling pathway and regulation of hematopoietic progenitor cell differentiation. Predicted to localize to  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb818 Small Deletion Unknown Unknown CRISPR
ioz8 Insertion Exon 1 Frameshift CRISPR
la021779Tg Transgenic Insertion Unknown Unknown DNA
Targeting reagents:
DISEASE ASSOCIATED WITH bloc1s2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH bloc1s2 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
Hermansky-Pudlak syndrome bloc1s2ihb818/ihb818 standard conditions Chen et al., 2018
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of lymphoid progenitor cell differentiation (more)
Cellular Component BLOC-1 complex (more)
Molecular Function gamma-tubulin binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR019269 (1)
  • Pfam:PF10046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bloc1s2-201 (1) 924
    bloc1s2-202 (1) 915
    bloc1s2-203 (1) 1019
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM bloc1s2 No data available
    MARKER RELATIONSHIPS
    bloc1s2Contained in: [BAC] CH211-257M21 (1) (order this)
    bloc1s2Encodes: [cDNA] MGC:111974 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001033101 (1) 869bp
    Genomic GenBank:BX897740 (1) 160056bp
    Select Tool
    Polypeptide UniProtKB:A2BIA5 (1) 177aa
    Sequence Clusters UniGene:48553 (1)
    Sequence Information (all 19)
    ORTHOLOGY for bloc1s2 (Chr: 20)
    CITATIONS (25)