ZFIN ID: ZDB-GENE-050808-1
Gene Name: N-ethylmaleimide-sensitive factor b
Gene Symbol: nsfb    Nomenclature History

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Previous Names: unm_au13, unm_au18

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have ATPase activity. Involved in pigment granule maturation and retinal pigment epithelium development. Predicted to localize to Golgi stack. Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; pectoral fin bud; and swim bladder. Used to study oculocutaneous albinism. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase).
Genome Resources: Alliance (1),  Gene:554200 (1),  Ensembl(GRCz11):ENSDARG00000038991 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
au13 Unknown Unknown Unknown ENU
au18 Point Mutation Unknown Premature Stop ENU
hi2869Tg Transgenic Insertion Intron 18 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10323 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22087 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42022 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42023 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nsfb N/A 1
    DISEASE ASSOCIATED WITH nsfb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nsfb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    oculocutaneous albinism nsfbau13/au13 standard conditions Hanovice et al., 2015
    nsfbau18/au18(AB) standard conditions Hanovice et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pigment granule maturation (more)
    Cellular Component Golgi stack (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nsfb-201 (1)    Ensembl 2353
    nsfb-203 (1)    Ensembl 3466
    ncRNA nsfb-003 (1) 281
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nsfb No data available
    MARKER RELATIONSHIPS
    nsfb Contained in: [BAC] CH211-177M15 (1), DKEY-38P12 (1) (order this)
    nsfb Encodes: [cDNA] MGC:194633 (1), MGC:194652 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001024454 (1) 2400 nt
    Genomic GenBank:AL929346 (1) 232537 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DHK0 (1) 747 aa
    Sequence Information (all 27)
    ORTHOLOGY for nsfb ( Chr: 12 )
    CITATIONS (32)