Gene
nsfb
- ID
- ZDB-GENE-050808-1
- Name
- N-ethylmaleimide-sensitive factor b
- Symbol
- nsfb Nomenclature History
- Previous Names
-
- unm_au13
- unm_au18
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity. Involved in pigment granule maturation and retinal pigment epithelium development. Predicted to localize to Golgi stack. Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; pectoral fin bud; and swim bladder. Used to study oculocutaneous albinism. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase).
- Genome Resources
- Note
- None
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
oculocutaneous albinism | nsfbau13/au13 | standard conditions | Hanovice et al., 2015 |
oculocutaneous albinism | nsfbau18/au18(AB) | standard conditions | Hanovice et al., 2015 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
Domain | IPR003338 | CDC48, N-terminal subdomain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR003959 | ATPase, AAA-type, core |
Domain | IPR004201 | CDC48, domain 2 |
Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
Family | IPR039812 | Vesicle-fusing ATPase |
Homologous_superfamily | IPR009010 | Aspartate decarboxylase-like domain superfamily |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR029067 | CDC48 domain 2-like superfamily |
Domain Details Per Protein
Protein | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | Aspartate decarboxylase-like domain superfamily | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | CDC48, domain 2 | CDC48 domain 2-like superfamily | CDC48, N-terminal subdomain | P-loop containing nucleoside triphosphate hydrolase | Vesicle-fusing ATPase |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q4U0S6
|
747 | ||||||||||
UniProtKB:F1QGG3
|
747 | ||||||||||
UniProtKB:A0A0R4IGS4
|
744 | ||||||||||
UniProtKB:B3DHK0
|
747 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl