ZFIN ID: ZDB-GENE-050706-89
Gene Name: FYN proto-oncogene, Src family tyrosine kinase b
Gene Symbol: fynb    Nomenclature History

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Previous Names: fyn-like (1), im:6908851, si:dkey-119m7.5, zgc:109996

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in convergent extension involved in gastrulation; fin regeneration; and regulation of protein kinase activity. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
Genome Resources: Alliance (1),  Gene:574422 (1),  Ensembl(GRCz11):ENSDARG00000025319 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Yoo et al., 2012
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3055 Point Mutation Unknown Premature Stop ENU
sa17760 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18008 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fyna,fynb N/A 7
    MO1-fynb N/A 1
    MO2-fynb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fynb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fynb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fynb-201 (1)    Ensembl 2146
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fynb No data available
    MARKER RELATIONSHIPS
    fynb Contained in: [BAC] CH73-67G20 (1), CH73-310L15, DKEY-119M7 (order this)
    fynb Encodes: [cDNA] MGC:109996 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001029969 (1) 2101 nt
    Genomic GenBank:AL954744 (1) 166911 nt
    Select Tool
    Polypeptide UniProtKB:F1RDG9 (1) 544 aa
    Sequence Information (all 18)
    ORTHOLOGY for fynb ( Chr: 20 )
    CITATIONS (30)