ZFIN ID: ZDB-GENE-050706-185
Gene Name: GRB10 interacting GYF protein 2
Gene Symbol: gigyf2    Nomenclature History

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Previous Names: gigfy2 (1), fb57e02, im:6911549 (1), wu:fb57e02 (1), zgc:111944 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in blastoderm; blastodisc; brain; and somite. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2).
Genome Resources: Alliance (1),  Gene:561830 (1),  Ensembl(GRCz11):ENSDARG00000009735 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6911549]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a273 Complex Unknown Unknown CRISPR
la014995Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8785 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10322 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11852 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18439 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18740 Point Mutation Unknown Premature Stop ENU
    sa19880 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19881 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19882 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33025 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33026 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38357 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39934 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gigyf2 1
    CRISPR2-gigyf2 1
    CRISPR3-gigyf2 1
    CRISPR4-gigyf2 1
    MO1-gigyf2 N/A 1
    DISEASE ASSOCIATED WITH gigyf2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Parkinson disease 11} 607688
    DISEASE ASSOCIATED WITH gigyf2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biological_process (more)
    Cellular Component cellular_component (more)
    Molecular Function molecular_function (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003169 GYF domain
    Homologous_superfamily IPR035445 GYF-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gigyf2-201 (1)    Ensembl 4696
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gigyf2 No data available
    MARKER RELATIONSHIPS
    gigyf2 Contained in: [BAC] CH211-195J11 (1), CH211-204O10 (1), DKEYP-12A9 (1)
    gigyf2 Encodes: [EST] fb57e02, IMAGE:6911549 (1)
    [cDNA] MGC:111944 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030161 (1) 4706 nt
    Genomic GenBank:BX890608 (1) 194388 nt
    Select Tool
    Polypeptide UniProtKB:B0S7J5 (1) 1329 aa
    Sequence Information (all 18)
    ORTHOLOGY for gigyf2 ( Chr: 2 )
    CITATIONS (26)