Gene

cel.2

ID
ZDB-GENE-061110-10
Name
carboxyl ester lipase, tandem duplicate 2
Symbol
cel.2 Nomenclature History
Previous Names
  • cell
  • zgc:112377
  • zgc:153861
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have lipase activity; neurexin family protein binding activity; and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cel.2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 8 Alliance Maturity-onset diabetes of the young, type VIII 609812
Associated With cel.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019826 Carboxylesterase type B, active site
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Domain IPR002018 Carboxylesterase, type B
Family IPR000997 Cholinesterase
Family IPR033560 Bile salt-activated lipase
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Bile salt-activated lipase Carboxylesterase, type B Carboxylesterase type B, active site Carboxylesterase type B, conserved site Cholinesterase
UniProtKB:F6P131 551
UniProtKB:A0AUR3 550
UniProtKB:Q6P004 552
UniProtKB:Q4QRH4 550
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations