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Gene

ctss2.2

ID
ZDB-GENE-050626-55
Name
cathepsin S, ortholog 2, tandem duplicate 2
Symbol
ctss2.2 Nomenclature History
Previous Names
  • ctssb.2 (1)
  • ctssb2 (1)
  • wu:fj84d06
  • zgc:111950
  • zgc:112489
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in blood; macrophage; and yolk syncytial layer. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctss2.2 Human Ortholog
No data available
Associated With ctss2.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Domain IPR039417 Papain-like cysteine endopeptidase
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Cathepsin propeptide inhibitor domain (I29) Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine endopeptidase Papain-like cysteine peptidase superfamily Peptidase C1A, papain C-terminal
UniProtKB:Q566T8 330
UniProtKB:Q4QRH8 330
UniProtKB:A2BF64 330
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
This gene and ctssb.1 (ZDB-GENE-050522-559) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human CTSS and mouse Ctss based on amino acid identity and conserved location.
Citations