ZFIN ID: ZDB-GENE-050616-11
Gene Name: gap junction protein, alpha 5b
Gene Symbol: gja5b    Nomenclature History

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Previous Names: cx41.8, leo, leopard, tup (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits gap junction hemi-channel activity. Involved in adult behavior; melanocyte differentiation; and melanocyte migration. Predicted to localize to connexin complex. Is expressed in brain; eye; fin; heart; and integument. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5).
Genome Resources: Alliance (1),  Gene:570445 (1),  Ensembl(GRCz11):ENSDARG00000069450 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dmh7 Point Mutation Unknown Nonsynonymous ENU
dmh8 Point Mutation Unknown Nonsynonymous ENU
dt3oj022 Point Mutation Unknown Unknown ENU
dtk3 Point Mutation Unknown Unknown ENU
dtnr16 Point Mutation Unknown Unknown ENU
dtnz Point Mutation Unknown Unknown ENU
dtq270 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • dtw28 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • gja5b_unspecified Unspecified Unknown Unknown
    sa19565 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19566 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t1 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • to29 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • DISEASE ASSOCIATED WITH gja5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial standstill 1 Alliance Atrial standstill, digenic (GJA5/SCN5A) 108770
    familial atrial fibrillation Alliance Atrial fibrillation, familial, 11 614049
    DISEASE ASSOCIATED WITH gja5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pigmentation (more)
    Cellular Component cell junction (more)
    Molecular Function gap junction hemi-channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gja5b-201 (1)    Ensembl 2801
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gja5b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cx41.8:cx41.8) gja5b gja5b Danio rerio 1 4
    Tg(cx41.8:cx45.6) gja5b gja5a Danio rerio 1 2
    Tg(cx41.8:EGFP) gja5b EGFP Danio rerio 1 3
    Tg(mitfa:cx41.8) mitfa gja5b Danio rerio 1 4
    Tg(mitfa:gja5b_I203F) mitfa gja5b Danio rerio 1 1
    Tg2(mitfa:cx41.8) mitfa gja5b Danio rerio 1 3
    Tg3(mitfa:cx41.8) mitfa gja5b Danio rerio 2 3
    Tg4(mitfa:gja5b) mitfa gja5b Danio rerio 1 1
    MARKER RELATIONSHIPS
    gja5b Contained in: [BAC] CH73-191D11 (1)
    [Fosmid] CH1073-229O2 (1)
    gja5b Encodes: [cDNA] MGC:194821 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034988 (1) 2825 nt
    Genomic GenBank:CU896648 (1) 67673 nt
    Select Tool
    Polypeptide UniProtKB:B3DID2 (1) 370 aa
    Sequence Information (all 14)
    ORTHOLOGY for gja5b ( Chr: 1 )
    CITATIONS (84)