Gene

il12ba

ID
ZDB-GENE-050525-3
Name
interleukin 12Ba
Symbol
il12ba Nomenclature History
Previous Names
  • il-12p40.a (1)
  • il12b
  • zgc:152789
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have cytokine receptor activity and interleukin-12 alpha subunit binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to several cellular components, including external side of plasma membrane; interleukin-12 complex; and interleukin-23 complex. Is expressed in dendritic cell and intestine. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il12ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 29 Alliance Immunodeficiency 29, mycobacteriosis 614890
Associated With il12ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR019482 Interleukin-12 beta, central domain
Family IPR015528 Interleukin-12 beta
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III superfamily Immunoglobulin-like fold Interleukin-12 beta Interleukin-12 beta, central domain
UniProtKB:A8WH99 350
UniProtKB:Q6F3Q9 324
UniProtKB:B8JJU1 324
UniProtKB:Q0V941 324
UniProtKB:F1RA13 350
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations