ZFIN ID: ZDB-GENE-050523-2
Gene Name: large tumor suppressor kinase 1
Gene Symbol: lats1    Nomenclature History

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Previous Names: si:dkey-181i3.5, wu:fc19a11, zgc:123219

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Orthologous to human LATS1 (large tumor suppressor kinase 1).
Genome Resources: Alliance (1),  Gene:553164 (1),  Ensembl(GRCz11):ENSDARG00000003751 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021389Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ncv107 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
    sa36934 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2211 Indel Unknown Unknown CRISPR
    DISEASE ASSOCIATED WITH lats1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lats1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR000961 AGC-kinase, C-terminal
    Family IPR028741 Serine/threonine-protein kinase LATS1
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lats1-201 (1)    Ensembl 7030
    lats1-202 (1)    Ensembl 2552
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lats1 No data available
    MARKER RELATIONSHIPS
    lats1 Contained in: [BAC] DKEY-181I3 (1) (order this)
    lats1 Encodes: [EST] fc19a11
    [cDNA] MGC:123219 (1), MGC:175000 (1), MGC:198071 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020510 (1) 3207 nt
    Genomic GenBank:BX248418 (1) 152757 nt
    Select Tool
    Polypeptide UniProtKB:Q58FB8 (1) 1068 aa
    Sequence Information (all 30)
    ORTHOLOGY for lats1 ( Chr: 20 )
    CITATIONS (33)