Gene
lats1
- ID
- ZDB-GENE-050523-2
- Name
- large tumor suppressor kinase 1
- Symbol
- lats1 Nomenclature History
- Previous Names
-
- si:dkey-181i3.5
- wu:fc19a11
- zgc:123219
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Orthologous to human LATS1 (large tumor suppressor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Chen et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant polycystic kidney disease | lats1zf2211/zf2211 | standard conditions | Xu et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:A9JTE1
|
632 | |||||
|
UniProtKB:Q58FB8
|
1068 | |||||
|
UniProtKB:Q5RIL6
|
1068 |
Interactions and Pathways
No data available
Plasmids
No data available