Gene

gli2b

ID
ZDB-GENE-050523-1
Name
GLI family zinc finger 2b
Symbol
gli2b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in central nervous system development and dorsal/ventral pattern formation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Is expressed in adenohypophyseal placode; central nervous system; neural keel; and neural tube. Orthologous to human GLI2 (GLI family zinc finger 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gli2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Culler-Jones syndrome Alliance Culler-Jones syndrome 615849
holoprosencephaly 9 Alliance Holoprosencephaly 9 610829
Associated With gli2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Family IPR043359 C2H2-type zinc-finger protein GLI-like
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length C2H2-type zinc-finger protein GLI-like Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1QH64 1225
UniProtKB:Q5BN24 1363
UniProtKB:B3DGN8 1363
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations