Gene

lims2

ID
ZDB-GENE-050522-56
Name
LIM and senescent cell antigen-like domains 2
Symbol
lims2 Nomenclature History
Previous Names
  • hm:zeh0381 (1)
  • pinch2 (1)
  • zeh0381
  • zgc:112257
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity. Involved in heart contraction and regulation of protein kinase B signaling. Predicted to localize to cell-cell junction; cytoplasm; and focal adhesion. Is expressed in adaxial cell; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to several human genes including LIMS1 (LIM zinc finger domain containing 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Meder et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lims2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2W Alliance ?Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue 616827
Associated With lims2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001781 Zinc finger, LIM-type
Family IPR017351 LIM and senescent cell antigen-like-containing domain protein 1-like
Domain Details Per Protein
Protein Length LIM and senescent cell antigen-like-containing domain protein 1-like Zinc finger, LIM-type
UniProtKB:F1QKL9 333
UniProtKB:F1R9E2 377
UniProtKB:Q502G3 377
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations