ZFIN Gene: ints8

ZFIN ID: ZDB-GENE-050522-556

ZFIN ID: ZDB-GENE-050522-556

Gene Name:

integrator complex subunit 8

Gene Symbol:

ints8 Nomenclature History

Previous Name:

zgc:111823 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 19 Mapping Details/Browsers

Description:

Predicted to be involved in snRNA 3'-end processing. Predicted to localize to the integrator complex. Orthologous to human INTS8 (integrator complex subunit 8).

Genome Resources:

Alliance (1), Gene:553794 (1), Ensembl(GRCz11):ENSDARG00000057986 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:111823]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la011625Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la013399Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa6551	Point Mutation	Unknown	Splice Site	ENU
sa11804	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23499	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23500	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23501	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23502	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43260	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH ints8 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Neurodevelopmental disorder with cerebellar hypoplasia and spasticity	618572

DISEASE ASSOCIATED WITH ints8 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	snRNA 3'-end processing (more)
Cellular Component	integrator complex (more)

GO Terms (all 2)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR011990 (1) InterPro:IPR038751 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ints8-202 (1)	3272	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ints8-203 (1)	470	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ints8-205 (1)	829	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ints8-206 (1)	761	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ints8-002 (1)	667	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ints8 No data available

MARKER RELATIONSHIPS

ints8 Contained in:	[BAC] CH211-185O22 (1) (order this), DKEY-126H23 (1) (order this), DKEYP-26F11 (1)
ints8 Encodes:	[cDNA] MGC:111823 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001020756 (1)	1842 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR388100 (1)	138214 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A3KQN9 (1)	996 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:45537 (1)

Sequence Information (all 23)

ORTHOLOGY for ints8 ( Chr: 19 )

CITATIONS (24)

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