Gene
gfi1aa
- ID
- ZDB-GENE-050522-534
- Name
- growth factor independent 1A transcription repressor a
- Symbol
- gfi1aa Nomenclature History
- Previous Names
-
- gfi1.1
- gfi1a
- zgc:113277 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation and primitive hemopoiesis. Predicted to localize to nucleoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pancreas; and sensory system. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158523 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
myelodysplastic syndrome | gfi1aaszy5/szy5; i114Tg/i114Tg | standard conditions | Wu et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|
UniProtKB:Q501T1
|
385 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
gfi1aa-201
(1)
|
Havana | 1464 nt | |
mRNA |
gfi1aa-202
(1)
|
Ensembl | 1607 nt |
Interactions and Pathways
No data available
Plasmids
No data available