ZFIN ID: ZDB-GENE-050522-492
Gene Name: polypyrimidine tract binding protein 1a
Gene Symbol: ptbp1a    Nomenclature History

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Previous Names: brb, ptbp1, brom bones (1), hnRNP I (1), wu:fb99f12, zgc:110689

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Involved in several processes, including intestinal epithelial structure maintenance; negative regulation of Notch signaling pathway; and positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration. Predicted to localize to the nucleus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1).
Genome Resources: Alliance (1),  Gene:323490 (1),  Ensembl(GRCz11):ENSDARG00000019362 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p50ada Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17243 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH ptbp1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ptbp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component nucleus (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Family IPR006536 HnRNP-L/PTB
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    Domain IPR021790 PTBP1, RNA recognition motif 2-like
    Domain IPR034798 Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2
    Domain IPR035000 PTBP1, RNA recognition motif 1
    Domain IPR035001 PTBP1, RNA recognition motif 3
    Homologous_superfamily IPR035979 RNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptbp1a-201 (1)    Ensembl 3855
    ncRNA ptbp1a-002 (1)    Ensembl 541
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptbp1a No data available
    MARKER RELATIONSHIPS
    ptbp1a Contained in: [BAC] DKEY-57I11 (1) (order this)
    ptbp1a Encodes: [EST] fb99f12 (1)
    [cDNA] MGC:110689 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020477 (1) 3723 bp
    Genomic GenBank:CR788230 (1) 222975 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q503D3 (1) 574 aa
    Sequence Information (all 15)
    ORTHOLOGY for ptbp1a ( Chr: 2 )
    CITATIONS (31)