Gene

hrasb

ID
ZDB-GENE-050522-466
Name
HRas proto-oncogene, GTPase b
Symbol
hrasb Nomenclature History
Previous Names
  • hrasl
  • zgc:110734
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hrasb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bladder cancer, somatic 109800
Congenital myopathy with excess of muscle spindles 218040
Costello syndrome 218040
Nevus sebaceous or woolly hair nevus, somatic 162900
Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
Spitz nevus or nevus spilus, somatic 137550
Thyroid carcinoma, follicular, somatic 188470
Associated With hrasb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR020849 Small GTPase, Ras-type
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase, Ras-type Small GTP-binding protein domain
UniProtKB:Q503B6 189
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations