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ZIRC
ZFIN ID: ZDB-GENE-050522-466
Gene Name: HRas proto-oncogene, GTPase b
Gene Symbol: hrasb    Nomenclature History

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Previous Names: hrasl, zgc:110734

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
Genome Resources: Alliance (1),  Gene:553656 (1),  Ensembl(GRCz11):ENSDARG00000005651 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13032 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hrasb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Costello syndrome Alliance Congenital myopathy with excess of muscle spindles 218040
    Costello syndrome 218040
    epidermal nevus Alliance Nevus sebaceous or woolly hair nevus, somatic 162900
    large congenital melanocytic nevus Alliance Spitz nevus or nevus spilus, somatic 137550
    linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
    thyroid gland follicular carcinoma Alliance Thyroid carcinoma, follicular, somatic 188470
    urinary bladder cancer Alliance Bladder cancer, somatic 109800
    DISEASE ASSOCIATED WITH hrasb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component membrane (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript hrasb-202 (1)    Ensembl 842
    mRNA hrasb-201 (1)    Ensembl 2805
    hrasb-203 (1)    Ensembl 629
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hrasb No data available
    MARKER RELATIONSHIPS
    hrasb Contained in: [BAC] CH211-210P4 (1) (order this)
    hrasb Encodes: [cDNA] MGC:110734 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020629 (1) 2657 bp
    Genomic GenBank:BX088691 (1) 150021 bp
    Select Tool
    Polypeptide UniProtKB:Q503B6 (1) 189 aa
    Sequence Clusters UniGene:8916 (1)
    Sequence Information (all 11)
    ORTHOLOGY for hrasb ( Chr: 7 )
    CITATIONS (20)