Gene

hrasb

ID

ZDB-GENE-050522-466

Name

HRas proto-oncogene, GTPase b

Symbol

hrasb Nomenclature History

Previous Names

hrasl
zgc:110734

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hrasb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Costello syndrome	Alliance	Congenital myopathy with excess of muscle spindles	218040
Costello syndrome	Alliance	Costello syndrome	218040
epidermal nevus	Alliance	Nevus sebaceous or woolly hair nevus, somatic	162900
follicular thyroid carcinoma	Alliance	Thyroid carcinoma, follicular, somatic	188470
large congenital melanocytic nevus	Alliance	Spitz nevus or nevus spilus, somatic	137550
linear nevus sebaceous syndrome	Alliance	Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic	163200
urinary bladder cancer	Alliance	Bladder cancer, somatic	109800

Associated With hrasb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR020849	Small GTPase, Ras-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	P-loop containing nucleoside triphosphate hydrolase	Small GTPase	Small GTPase, Ras-type	Small GTP-binding domain
UniProtKB:Q503B6 InterPro	189

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hrasb-202 (1) Ensembl	Ensembl	842 nt	Select Tool
mRNA	hrasb-201 (1) Ensembl	Ensembl	2,805 nt	Select Tool
mRNA	hrasb-203 (1) Ensembl	Ensembl	629 nt	Select Tool
mRNA	hrasb-204 (1) Ensembl	Ensembl	2,667 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations