Gene
ern1
- ID
- ZDB-GENE-050522-431
- Name
- endoplasmic reticulum to nucleus signaling 1
- Symbol
- ern1 Nomenclature History
- Previous Names
-
- sb:eu1005
- zgc:109932
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have endoribonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Involved in response to hypoxia. Predicted to localize to IRE1-TRAF2-ASK1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).
- Genome Resources
- Note
- None
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR010513 | KEN domain |
Domain | IPR018997 | PUB domain |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR038357 | KEN domain superfamily |
Repeat | IPR018391 | Pyrrolo-quinoline quinone beta-propeller repeat |
Domain Details Per Protein
Protein | Length | KEN domain | KEN domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | PUB domain | Pyrrolo-quinoline quinone beta-propeller repeat | Quinoprotein alcohol dehydrogenase-like superfamily | Serine/threonine-protein kinase, active site | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q504E3
|
292 | |||||||||
UniProtKB:F1QYL2
|
1031 | |||||||||
UniProtKB:X1WEF9
|
960 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl