Gene

ern1

ID

ZDB-GENE-050522-431

Name

endoplasmic reticulum to nucleus signaling 1

Symbol

ern1 Nomenclature History

Previous Names

sb:eu1005
zgc:109932

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have endoribonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Involved in response to hypoxia. Predicted to localize to IRE1-TRAF2-ASK1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).

Genome Resources

Note

None

Expression

All Expression Data

13 figures from 11 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

MGC:109932 (1 image)
eu1005 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ern1 Human Ortholog

No data available

Associated With ern1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR010513	KEN domain
Domain	IPR018997	PUB domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR038357	KEN domain superfamily
Repeat	IPR018391	Pyrrolo-quinoline quinone beta-propeller repeat

Domain Details Per Protein

Protein	Length	KEN domain	KEN domain superfamily	Protein kinase domain	Protein kinase-like domain superfamily	PUB domain	Pyrrolo-quinoline quinone beta-propeller repeat	Quinoprotein alcohol dehydrogenase-like superfamily	Serine/threonine-protein kinase, active site	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q504E3 InterPro	292
UniProtKB:F1QYL2 InterPro	1031
UniProtKB:X1WEF9 InterPro	960

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ern1-202 (1) Ensembl	2996 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ern1-002 (1) Ensembl	344 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations