ZFIN ID: ZDB-GENE-050522-421
Gene Name: NADH:ubiquinone oxidoreductase subunit S4
Gene Symbol: ndufs4    Nomenclature History

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Previous Name: zgc:112289

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport chain. Predicted to localize to mitochondrial respiratory chain complex I. Is expressed in brain; myotome; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in Leigh disease and mitochondrial complex I deficiency. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4).
Genome Resources: Alliance (1),  Gene:573689 (1),  Ensembl(GRCz11):ENSDARG00000052840 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6907533]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nei013 Unknown Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
TALEN1-ndufs4
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ndufs4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitochondrial complex I deficiency Alliance Mitochondrial complex I deficiency, nuclear type 1 252010
DISEASE ASSOCIATED WITH ndufs4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process electron transport chain (more)
Cellular Component membrane (more)
Molecular Function oxidoreductase activity, acting on NAD(P)H (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ndufs4-201 (1)    Ensembl 629
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ndufs4 No data available
MARKER RELATIONSHIPS
ndufs4 Contained in: [BAC] DKEY-111K10 (1) (order this)
ndufs4 Encodes: [EST] IMAGE:6907533 (1)
[cDNA] MGC:112289 (1), MGC:174640 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001020676 (1) 618 nt
Genomic GenBank:BX537294 (1) 204048 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q502E4 (1) 168 aa
Sequence Information (all 14)
ORTHOLOGY for ndufs4 ( Chr: 5 )
CITATIONS (25)