ZFIN ID: ZDB-GENE-050522-415
Gene Name: eph receptor B2b
Gene Symbol: ephb2b    Nomenclature History

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Previous Names: fi18g12, wu:fi18g12 (1), zgc:112296 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in central nervous system projection neuron axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).
Genome Resources: Alliance (1),  Gene:554232 (1),  Ensembl(GRCz11):ENSDARG00000021539 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027261Tg Transgenic Insertion Unknown Unknown DNA
sa41856 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ephb2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Bleeding disorder, platelet-type, 22 618462
    {Prostate cancer/brain cancer susceptibility, somatic} 603688
    DISEASE ASSOCIATED WITH ephb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ephb2b-201 (1)    Ensembl 8285
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ephb2b No data available
    MARKER RELATIONSHIPS
    ephb2b Contained in: [BAC] CH211-69J23 (1), DKEY-189L3 (1) (order this)
    ephb2b Encodes: [EST] fi18g12
    ephb2b Has Artifact: [cDNA] MGC:112296 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001033094 (1) 2058 nt
    Genomic GenBank:CR450786 (1) 169832 nt
    Select Tool
    Polypeptide UniProtKB:A2CEJ3 (1) 989 aa
    Sequence Information (all 12)
    ORTHOLOGY for ephb2b ( Chr: 11 )
    CITATIONS (29)