Gene

ctns

ID
ZDB-GENE-050522-352
Name
cystinosin, lysosomal cystine transporter
Symbol
ctns Nomenclature History
Previous Names
  • zgc:110194
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have L-cystine transmembrane transporter activity. Involved in glomerular filtration; regulation of autophagy; and renal absorption. Predicted to localize to lysosomal membrane. Used to study cystinosis. Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctns Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cystinosis Alliance Cystinosis, atypical nephropathic 219800
cystinosis Alliance Cystinosis, late-onset juvenile or adolescent nephropathic 219900
cystinosis Alliance Cystinosis, nephropathic 219800
cystinosis Alliance Cystinosis, ocular nonnephropathic 219750
Associated With ctns Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR005282 Lysosomal cystine transporter
Repeat IPR006603 PQ-loop repeat
Domain Details Per Protein
Protein Length Lysosomal cystine transporter PQ-loop repeat
UniProtKB:F1QM07 384
UniProtKB:Q503T0 384
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations