Gene

sptlc2a

ID

ZDB-GENE-050522-23

Name

serine palmitoyltransferase, long chain base subunit 2a

Symbol

sptlc2a Nomenclature History

Previous Names

sptlc2
zgc:110661

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to localize to serine C-palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2).

Genome Resources

Note

None

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sptlc2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 1C	Alliance	Neuropathy, hereditary sensory and autonomic, type IC	613640

Associated With sptlc2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001917	Aminotransferase, class-II, pyridoxal-phosphate binding site
Domain	IPR004839	Aminotransferase, class I/classII
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Length	Aminotransferase, class I/classII	Aminotransferase, class-II, pyridoxal-phosphate binding site	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase domain 1	Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:F8W491 InterPro	236
UniProtKB:F1QCX4 InterPro	558
UniProtKB:Q503F0 InterPro	534

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
aberrant processed transcript	sptlc2a-204 (1) Ensembl	2017 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	sptlc2a-201 (1) Ensembl	1878 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sptlc2a-003 (1) Ensembl	703 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sptlc2a-004 (1) Ensembl	539 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations