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ZIRC
ZFIN ID: ZDB-GENE-050522-222
Gene Name: centrosomal protein 55 like
Gene Symbol: cep55l    Nomenclature History

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Previous Names: cep55 (1), zgc:112184

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Involved in cerebellum development; cranial skeletal system development; and regulation of intracellular signal transduction. Predicted to localize to the midbody. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Is expressed in several structures, including caudal fin; integument; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human CEP55 (centrosomal protein 55).
Genome Resources: Alliance (1),  Gene:553800 (1),  Ensembl(GRCz11):ENSDARG00000102349 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:112184]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
e48 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • la018337Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018338Tg Transgenic Insertion Unknown Unknown DNA
    la027372Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22018 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cep55l
    1
    MO1-cep55l N/A 1
    MO2-cep55l N/A 1
    MO3-cep55l N/A 1
    DISEASE ASSOCIATED WITH cep55l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly Alliance Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 236500
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum development (more)
    Cellular Component centriole (more)
    Molecular Function molecular_function (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR022008 (1)
  • InterPro:IPR038926 (1)
  • Pfam:PF12180 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cep55l-201 (1)    Ensembl 2200
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cep55l No data available
    MARKER RELATIONSHIPS
    cep55l Contained in: [BAC] CH211-149K17 (1) (order this)
    cep55l Encodes: [cDNA] MGC:112184 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020762 (1) 2184 bp
    Genomic GenBank:AL929469 (1) 146415 bp
    Select Tool
    Polypeptide UniProtKB:Q502I3 (1) 435 aa
    Sequence Clusters UniGene:20507 (1)
    Sequence Information (all 12)
    ORTHOLOGY for cep55l ( Chr: 12 )
    CITATIONS (27)