ZFIN ID: ZDB-GENE-050522-22
Gene Name: karyopherin alpha 5 (importin alpha 6)
Gene Symbol: kpna5    Nomenclature History

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Previous Names: im:7151662, zgc:110662 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to localize to the cytosol; nuclear pore; and nucleoplasm. Orthologous to human KPNA5 (karyopherin subunit alpha 5).
Genome Resources: Alliance (1),  Gene:553205 (1),  Ensembl(GRCz11):ENSDARG00000042030 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7151662]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027729Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39113 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kpna5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kpna5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein import into nucleus (more)
    Cellular Component cytoplasm (more)
    Molecular Function nuclear import signal receptor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002652 Importin-alpha, importin-beta-binding domain
    Family IPR024931 Importin subunit alpha
    Homologous_superfamily IPR011989 Armadillo-like helical
    Homologous_superfamily IPR016024 Armadillo-type fold
    Homologous_superfamily IPR036975 Importin-alpha, importin-beta-binding domain superfamily
    Repeat IPR000225 Armadillo
    Repeat IPR032413 Atypical Arm repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kpna5-201 (1)    Ensembl 3312
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kpna5 No data available
    MARKER RELATIONSHIPS
    kpna5 Contained in: [BAC] CH211-280C20 (1)
    kpna5 Encodes: [EST] IMAGE:7151662 (1)
    [cDNA] MGC:110662 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001018153 (1) 3339 nt
    Genomic GenBank:CT027708 (1) 88760 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9E5 (1) 539 aa
    Sequence Information (all 11)
    ORTHOLOGY for kpna5 ( Chr: 16 )
    CITATIONS (24)